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Adult T Cell Leukemia/Lymphoma

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Adult T cell leukemia/lymphoma (ATLL) is a neoplasm of CD4 + T cells, caused by human T cell lymphotrophic virus I (HTLV-I), manifested by skin infiltrates, hypercalcemia, visceral involvement, lytic bone lesions, and abnormal lymphocytes on the peripheral smears.



Causes:

* Generally the risk of NHL increases with advancing age. HL in the elderly is associated with a poorer prognosis than that observed in younger patients.

* Black hair dye, which for more than 20 years has been linked to higher rates of NHL.

* Inherited immunodeficiency diseases (severe combined immunodeficiency, ataxia telangiectasia, among a host of others)

* Viruses -- Human T-lymphotropic virus type I (HTLV-1) and Epstein-Barr virus are two infectious agents that increase the chance of developing non-Hodgkin's lymphoma.



Symptoms:

* Lymph node swelling, often in the upper body area.

* A lack of energy, general fatigue.

* Weight loss

* Fevers which can come and go. ;

* Night sweats - unexplained sweating at night, often drenching

* Itching

* Enlargement of the spleen may cause abdominal pain or discomfort.


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